hnRNPA2B1 regulates the alternative splicing of BIRC5 to promote gastric cancer progression
نویسندگان
چکیده
منابع مشابه
Role of Aberrant Alternative Splicing in Cancer
Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...
متن کاملAlternative splicing of spleen tyrosine kinase differentially regulates colorectal cancer progression
Spleen tyrosine kinase (SYK) has been reported as a potential tumor suppressor in colorectal cancer (CRC). However, the role of alternative splicing of SYK in carcinogenesis remains unclear. In the present study, SYK isoforms were overexpressed in the human CRC HCT 116 cell line using lentiviral expression vectors to investigate the biological functions of full length SYK [SYK(L)] and short for...
متن کاملAlternative Splicing and Tumor Progression
Alternative splicing is a key molecular mechanism for increasing the functional diversity of the eukaryotic proteomes. A large body of experimental data implicates aberrant splicing in various human diseases, including cancer. Both mutations in cis-acting splicing elements and alterations in the expression and/or activity of splicing regulatory factors drastically affect the splicing profile of...
متن کاملAlternative Splicing: Role in Cancer Development and Progression
1 Dipartimento di Biomedicina e Prevenzione, Università di Roma Tor Vergata, Via Montpellier 1, 00133 Roma, Italy 2 Fondazione Santa Lucia, Laboratorio di Neuroembriologia, Via del Fosso di Fiorano 64, 00143 Roma, Italy 3 Faculty of Health and Life Sciences, University of the West of England, Coldharbour Lane, Bristol BS16 1QY, UK 4 Istituto di Genetica Molecolare, Consiglio Nazionale delle Ric...
متن کاملConserved RNA secondary structures promote alternative splicing.
Pre-mRNA splicing is carried out by the spliceosome, which identifies exons and removes intervening introns. Alternative splicing in higher eukaryotes results in the generation of multiple protein isoforms from gene transcripts. The extensive alternative splicing observed implies a flexibility of the spliceosome to identify exons within a given pre-mRNA. To reach this flexibility, splice-site s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Cell International
سال: 2021
ISSN: 1475-2867
DOI: 10.1186/s12935-021-01968-y